Damamycin Pharmacodynamic waxaa iska leh antibiyootiga aminoglycoside, waxayna leedahay saameyn dhexdhexaad ah oo ka hortag ah oo ku saabsan noocyada kala duwan ee bakteeriyada gram-negative, sida escherichia coli, salmonella, shigella, proteus iyo wixii la mid ah. Waxay u nugul tahay streptococcus, pneumococcus, staphylococcus epidermidis iyo qaar ka mid ah mycoplasma (sida mycoplasma gallinarum, mycoplasma turkey, mycoplasma synovialis, iwm). Inta badan waa dareen la'aan streptococcus viridis iyo staphylococcus aureus. Waxay caadi ahaan u adkaysataa pseudomonas aeruginosa iyo treponemas. Bakteeriyada mindhicirku aad bay ugu adkaysanaysaa megamycin, laakiin ma muujiyaan iska caabbinta streptomycin. Lincomycin waxa uu leeyahay hawl-bakteeriyo wanaagsan oo ka dhan ah bakteeriyada anaerobic, sida clostridium, peptococcus, peptostreptococcus, clostridium tetanus, clostridium perfringens iyo inta badan actinomyces. Lincomycin wuxuu inta badan ku shaqeeyaa qaybta 50-aad ee ribosoomyada bakteeriyada, taas oo saamaysa isku-dhafka borotiinka iyadoo la joojinayo fiditaanka silsiladda peptide.
Pharmacokinetics kaliya 7% ee lincomycin ayaa la nuugo ka dib maamulka gudaha, laakiin waxay ilaalisaa diirada sare ee mareenka caloosha iyo mindhicirka. Xoojinta nudaha daawadu way ka hoosaysaa fiirsashada serum. Ma fududa in la galo dareeraha cerebrospinal ama isha, iyo heerka isku xidhka borotiinka balaasmaha maaha mid sarreeya. Daawooyinka intooda badan waxaa laga soo saaraa sifaynta glomerular qaabkoodii asalka ahaa. bioavailability ee lincomycin waa 30% ~ 40% oo leh nuugista liidata ee maamulka afka. Heerka nuugista iyo cadadka lincomycin waxaa lagu yarayn karaa quudin isku dhafan. Digaagga ayaa la siiyay 50mg oo alaabtan ah (ku milmay biyaha la cabbo) halkii kg ee miisaanka jidhka muddo 7 maalmood ah. Inta lagu jiro baaritaanka, plasma lincomycin wuxuu gaaray 0.14 μ g/ml, halka xoogga daguanmycin uu aad u yaraa. Kadib 7 maalmood ee baaritaanka, waxay dhaaftay 0.1μg/ml.
1. Marka lagu daro lincomycin, waxay si weyn u kordhin kartaa waxqabadka bakteeriyada lidka ku ah mycoplasma waxayna ballaarin kartaa bakteeriyada bakteeriyada.
2. Isku darka lincomycin iyo daawooyinka anticholinesterase waxay yareyn karaan waxtarka dambe.
3. Marka lagu daro erythromycin waxay leedahay saameyn liddi ku ah.
Antibiyootiga. Bakteeriyada Gram-negative, bakteeriyada Gram-positive iyo caabuqa mycoplasma.
Cabbitaan isku dhafan: 100g oo badeecadan ah oo lagu qasay biyo 200 ~ 300kg doofaarka iyo 50 ~ 100kg digaaga 3 ~ 5 maalmood. Quudinta isku dhafan: 100g quudin isku dhafan 100kg doofaarka iyo 50kg digaagga, loo isticmaalo 5 ilaa 7 maalmood.
Beero daryeelka caafimaadka: Laga bilaabo 7 maalmood ka hor dhalmada ilaa 7 maalmood ka dib dhalmada, 100g oo badeecadan ah waxaa lagu qasaa 100kg, ama 200kg biyo. Daryeelka caafimaadka Doofaarka: Kahor iyo ka dib naaska naaska iyo marxaladda xanaanada, 100g qas 100kg, ama 200kg oo biyo ah.
Wax falcelin xun ah lama arag marka loo isticmaalo sida waafaqsan isticmaalka iyo qiyaasta loo qoray.
